COBALAMIN MALABSORPTION | |
Ultimately, the final diagnosis is reached by exclusion of many differential diagnoses and can only be confirmed by genetic testing [Tanner MS et al. 2012] in patients with anemia, approximately 1% to 2% are due to B12 deficiency [Ankar A 2017] | |
Laboratory findings | Vitamin B12 inc (plasma) L-Homocystine inc (urine) Methylmalonic acid inc (urine) |
Symptoms | anemia anemia dementia EEG abnormalities [-] growth retardation, poor growth infections (severe or recurrent) mental retardation muscle weakness neurological deterioration neutropenia (decreased neutrophils) onset, adolescent onset, adulthood onset, childhood onset, infancy progressive neurologic defect speech development, delayed, abnormal thrombopenia, thrombocytopenia |