LIVER DISEASE, LIVER FAILURE, UNSPECIFIC [DD]

Question 1

What is  LIVER DISEASE, LIVER FAILURE, UNSPECIFIC [DD]?

Accepted Answer

unspecific liver disease/liver failure:
-infectious: Hepatitis A, B, C, Parvovirus B19, Echovirus 9, Coxsackie virus, Adenovirus, HSV, EBV, CMV, Rubella, Syphilis, Toxoplasma, Human Herpas virus 6)
-adverse drug reactions (both toxic and hepatitic)
- hemophagocytic lymphohistiocytosis
- infiltrative diseases
- irradiation damage
- long-term TPN
- vascular anomalies/tumors (hemangioma and arteriovenous malformation )
- neonatal lupus erythomatosus
- hepatic neuroblastoma
- Budd-Chiari-Syndrome
- progressive familial intrahepatic cholestasis (Byler)
- hereditary fructose intolerance
- inborn errors of oxidative phosphorylation
- neonatal hemochromatosis
- tyrosinemia
- alpha 1 antitrypsin deficiency
- Wilsons disease
- galactosemia
- alpha-1-antitrypsin deficiency
- Zellweger syndrome
- Niemann Pick disease type C
- Glycogen storage disease type IV
- mitochondrial DNA depletion syndrome

Question 2

Gibt es eine deutsche Bezeichnung?

Accepted Answer

Leberversagen, Lebererkrankungen, unspezifisch [DD]

Disease	LIVER DISEASE, LIVER FAILURE, UNSPECIFIC [DD]
Gene locus
ICD
Summary	unspecific liver disease/liver failure: -infectious: Hepatitis A, B, C, Parvovirus B19, Echovirus 9, Coxsackie virus, Adenovirus, HSV, EBV, CMV, Rubella, Syphilis, Toxoplasma, Human Herpas virus 6) -adverse drug reactions (both toxic and hepatitic) - hemophagocytic lymphohistiocytosis - infiltrative diseases - irradiation damage - long-term TPN - vascular anomalies/tumors (hemangioma and arteriovenous malformation ) - neonatal lupus erythomatosus - hepatic neuroblastoma - Budd-Chiari-Syndrome - progressive familial intrahepatic cholestasis (Byler) - hereditary fructose intolerance - inborn errors of oxidative phosphorylation - neonatal hemochromatosis - tyrosinemia - alpha 1 antitrypsin deficiency - Wilsons disease - galactosemia - alpha-1-antitrypsin deficiency - Zellweger syndrome - Niemann Pick disease type C - Glycogen storage disease type IV - mitochondrial DNA depletion syndrome
Laboratory findings	Methionine normal/inc (plasma) N-Acetyltryptophane inc (urine) N-Acetyltyrosine inc (urine) Ammonia inc (blood) bleeding time dec (blood) DL-Kynurenin normal/inc (urine) L-Lactic acid normal/inc (blood) L-Lactic acid inc (urine) pH normal/dec (blood) Transaminases (ASAT/ALAT) normal/inc (serum)
Symptoms	encephalopathy liver failure ascites bleeding tendencies, hemorrhages Coagulopathy/Coagulation factors coma early death hepatomegaly (large liver) hyperammonemia hypotension jaundice lactic acidosis onset, adolescent onset, childhood onset, infancy onset, neonatal Organic acids, urine pruritus seizures teleangiectasia thromboembolism